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Khan, Habiba
- Antioxidant and Anti-Apoptotic Activities of Phytochemically Validated Fruit Extract of Solanum xanthocarpum in Primary Chondrocytes
Abstract Views :331 |
PDF Views:120
Authors
Neelam Shivnath
1,
Vineeta Rawat
1,
Sahabjada
1,
Asif Jafri
1,
Juhi Rais
1,
Habiba Khan
1,
Md. Arshad
1
Affiliations
1 Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow – 226007, Uttar Pradesh, IN
1 Molecular Endocrinology Lab, Department of Zoology, University of Lucknow, Lucknow – 226007, Uttar Pradesh, IN
Source
Journal of Ecophysiology and Occupational Health, Vol 18, No 3-4 (2018), Pagination: 106-116Abstract
The chondrocyte death may contribute in progression of osteoarthritis (OA). Solanum xanthocarpum (Family: Solanaceae) fruits were known for antioxidant activity. This study demonstrates that the phytochemically validated Solanum xanthocarpum fruits (SXF) extract has inhibitory activities on nitric oxide (NO) induced cell death and ROS formation in primary cultured chondrocytes. Chondrocyte death was induced by 1.5 mM of Sodium Nitroprusside (SNP). The Cell viability was measured by MTT assay and nuclear changes were observed by DAPI and Hoechst-PI. Antioxidant activity of SXF was demonstrated in H2O2 induced ROS generation in chondrocytes. Indomethacin (IM) (25μM), a NSAID was taken as positive control. Phytochemical analysis revealed the presence of flavonoids, anthraquinone glycosides, steroids, alkaloids, terpenoids and tannins. SXF significantly reduces the cell death induced by SNP in a dose dependent manner. The fluorescent photomicrograph of DAPI, Hoechst-PI and ROS also revealed the decreased rate of apoptosis in a dose-dependent manner. This study suggests that SXF shows anti-apoptotic and antioxidant activity in chondrocytesKeywords
Apoptosis, Chondrocytes, Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), Osteoarthritis, Phytochemicals.Full Text
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- Association of Cytokine TNF-α in Development of Osteoarthritis: A Comprehensive Study
Abstract Views :242 |
PDF Views:119
Authors
Affiliations
1 Department of Zoology, Experimental and Public Health Laboratory, University of Lucknow, Lucknow − 226007, IN
2 Department of Zoology, Molecular Endocrinology Lab, University of Lucknow, Lucknow − 226007, IN
3 Department of Orthopaedics, King George Medical University, Lucknow − 226003, IN
1 Department of Zoology, Experimental and Public Health Laboratory, University of Lucknow, Lucknow − 226007, IN
2 Department of Zoology, Molecular Endocrinology Lab, University of Lucknow, Lucknow − 226007, IN
3 Department of Orthopaedics, King George Medical University, Lucknow − 226003, IN
Source
Journal of Ecophysiology and Occupational Health, Vol 18, No 3-4 (2018), Pagination: 117-121Abstract
Osteo-Arthritis (OA) is a disease of joints affecting the normal functions of joint and causes physical disability. Many factors are responsible for development of osteoarthritis including over age, obesity, gender, drug abuse, over load on joints and genetic factors. OA causes health problems and impairs the quality of life with increased economic burden across the world. Apart from the pro-inflammatory role of cytokine Interleukin-1 (IL-1) in osteoarthritis, Tumor necrosis factor-alpha (TNF-α) is also involved in the progression of osteoarthritis. Members of TNF family are secreted from lymphocytes and natural killer cells but in OA patients it is also secreted from chondrocyte cells to influence the catabolic processes in Extra Cellular Matrix (ECM) by inducing the activity of matrix metaloproteinases (MMPs). In promoter region, most of the Single nucleotide polymorphisms (SNPs) of TNF-α located on -863, -857, -308, and -238. These SNPs are involved in various diseases including OA, rheumatoid Arthritis, systemic lupus erythematosus etc. Significance association of SNP -G308A of the TNF-α gene in OA has been observed in various studies. Aim of this mini review is to conclude the fundamental roles of TNF-α cytokine in patients with OA.Keywords
Cytokine, Gene Variants, Osteoarthritis, Pathophysiology, TNF-α.Full Text
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